Inverse correlation between plasma 3-chlorotyrosine and pinch strength in chronic kidney disease patients
▪ Author : R Liufu, S Hu, L Liu, Y Liu, C Li, H Hu, L Mi, R Tan
▪ Keyword : chronic kidney disease, sarcopenia, myeloperoxidase, 3-chlorotyrosine, muscle strength
▪ Content : Background and Objectives: This cross-sectional study aimed to explore whether plasma myeloperoxidase (MPO) and its active product, 3-chlorotyrosine (3-CT), as markers of inflammation and oxidative stress, have any independent pathophysiological association with sarcopenia-related parameters in patients with chronic kidney disease (CKD). Methods and Study Design: A total of 292 patients, including 147 on maintenance hemodialysis (HD) and 145 non-dialyzed hospitalized patients with CKD stages 1-5, were enrolled from September 2022 to December 2023 and categorized into three groups: CKD stages 1-2, CKD stages 3-5 (non-dialysis), and CKD stage 5 (HD).