Energy regulation in newly diagnosed TB with chronic energy deficiency: free fatty acids and RBP4
▪ Author : NA Taslim, D Virani, NK Sumartini, Karmila, A Bukhari, Aminuddin, Suryani, R Satriono, S Rasyid, I Djaharuddin
▪ Keyword : tuberculosis, malnutrition, free fatty acids, retinol binding protein 4, asymmetric dimethylarginine
▪ Content : Background and objectives: Energy metabolism may be dysfunctionally integral between host and infective
agent in active tuberculosis, mediated by adipocytokines and free fatty acids (FFA) as the products of triglyceride lipolysis in fat, blood or other tissues. Retinol Binding Protein 4 (RBP4) and asymmetric dimethylarginine (ADMA) are candidate adipocytokines. The possibility of a deleterious metabolic nexus in chronic energy deficiency (CED) (BMI <18.5 kg/m
2) is explored.