Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies
▪ Author : Y Xin, L Wu, X Lu, S Shangguan, Z Wang, S Chang, J Yu, W Piao, T Zhang, L Wang
▪ Keyword : methylenetetrahydrofolate reductase, A1298C, polymorphism, folate concentration, meta-analysis
▪ Content : Background and Objectives: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10-
methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. Previous studies suggest that MTHFR polymorphism influences folate metabolism, but conflicting results are reported. We performed a meta-analysis to accurately characterize the association between MTHFR A1298C polymorphism and peripheral blood folate concentration in healthy populations.