Effects of gamma-glutamyl carboxylase gene polymorphism (R325Q) on the association between dietary vitamin K intake and gamma-carboxylation of osteocalcin in young adults
▪ Author : M Haraikawa, N Tsugawa, N Sogabe, R Tanabe, Y Kawamura, T Okano, T Hosoi, M Goseki-Sone
▪ Keyword : vitamin K intake, phylloquinone (PK), menaquinone-7 (MK-7), single nucleotide polymorphisms (SNP), gamma-glutamyl carboxylase (GGCX)
▪ Content : Introduction: It has been demonstrated that single nucleotide polymorphism (SNP) (R325Q, 974G>A) in the gamma-glutamyl carboxylase (GGCX) gene is associated with the bone mineral density (BMD). In the present study, we investigated the effect of GGCX polymorphism (974G>A) on the correlations among the vitamin K intake, level of serum vitamin K, and ratio of undercarboxylated osteocalcin (ucOC) to intact osteocalcin (OC) in healthy young Japanese subjects.