Pancreatic exocrine insufficiency in malnourished children and those with persistent diarrhoea
▪ Author : AD Widodo, IS TIman, S Bardosono, W Winarta, D Prasetyo, A Firmansyah
▪ Keyword : persistent diarrhoea, undernutrition, exocrine pancreatic insufficiency, faecal elastase-1, children
▪ Content : Background and Objectives: Persistent diarrhoea, a serious health problem, is closely related to malnutrition. Children with severe malnutrition have a 9-fold risk of death, and children with severe stunting have a 4-fold risk of death. Prolonged mucosal injury from diarrhoea causes reduced secretin and cholecystokinin secretion, which
decreases stimulation to the pancreas, and is indicated by faecal elastase-1 levels. This further aggravates persistent diarrhoea and malnutrition because of the low levels of digestive enzyme production. This study evaluated the exocrine function of the pancreas in children with persistent diarrhoea and malnutrition.